January 1, 2000European Respiratory Journal

Maturational changes of endothelial vasoactive factors and pulmonary vascular tone at birth

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Population

Piglets aged <2 h, 2-3 day, 10 day and adult pigs (intrapulmonary artery rings and lung tissues)

Comparison

Pharmacological evaluation with acetylcholine… vs Comparison across age groups and between rings…

Design

Preclinical

Authors

MLMichael LévyWeizmann Institute of Science ESEvelyne SouilCentre National de la Recherche Scientifique SSS. SabryBeni-Suef University

Discussion

Member takes

Implication

May inform early postnatal management of neonatal pulmonary hypertension; leaves open human translation from this animal model.

Structured PICO

Population

Piglets aged <2 h, 2-3 day, 10 day and adult pigs (intrapulmonary artery rings and lung tissues)

Intervention

Pharmacological evaluation with acetylcholine (ACh) and cromakalim (CMK) in the presence and absence of L-NA, glibenclamide, and BQ123

Comparator

Comparison across age groups (<2 h, 2-3 day, 10 day, adult) and between rings with/without endothelium

Outcome

Pharmacological responses (relaxation/contraction) of intrapulmonary artery rings and expression of NOS and ETsurrogate

The decrease in pulmonary vascular resistance at birth is associated with a maturational shift from endothelin-mediated vasoconstriction to nitric oxide-mediated vasodilation within the first 2 days of life.

Cite This Study

Lévy et al. (2000) studied this question.

synapsesocial.com/papers/6a87e183e6314279fbfb12f3 https://doi.org/10.1183/09031936.00.15115800

View Full Paper

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Maturational changes of endothelial vasoactive factors and pulmonary vascular tone at birth

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Maturational changes of endothelial vasoactive factors and pulmonary vascular tone at birth

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider