Key result
Adult pigs exhibit ~2x higher cerebral endothelial NO synthase activity than newborns, while cyclooxygenase remains unaltered.
Authors
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Suggests caution extrapolating adult porcine cerebrovascular data to neonates; leaves open human developmental relevance.
Parfenova et al. (2000) studied this question. Postnatal development (adult age) vs. Newborn age was evaluated on Expression and activities of NO synthase and cyclooxygenase in cerebral microcirculation. In the cerebral circulation of pigs, endothelial NO synthase expression and activity is two- to threefold higher in adults compared to newborns, whereas cyclooxygenase is not altered.
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