Population
Rat models and tissues (pituitary, circumventricular organs, kidney)
Comparison
Physiological stressors vs Baseline/control conditions
Design
Preclinical
Authors
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Demonstrates tissue-specific AII receptor upregulation during animal dehydration; leaves open relevance to human salt balance or hypertension.
Angiotensin II receptors undergo tissue-specific dynamic regulation, with upregulation in the subfornical organ during dehydration and abundant high-affinity receptors identified in the renal medulla.
Mendelsohn et al. (1983) studied this question.
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