Why the study?
Does the ACE inhibitor SQ 20,881 affect angiotensin-induced drinking behavior?
Does the ACE inhibitor SQ 20,881 affect angiotensin-induced drinking behavior?
SQ 20,881 inhibits brain ACE after central but not peripheral administration, affecting angiotensin I-induced drinking behavior.
Central ACE inhibition modulates thirst in animals; leaves open relevance to human fluid balance or ACE inhibitor effects.
The effects of an ACE inhibitor, SQ 20,881, on the dipsogenic response to centrally administered angiotensins I and II were investigated. Central pretreatment with the inhibitor antagonized drinking behavior induced by angiotensin I, but not by angiotensin II. Peripheral treatment with 20,881 did not affect drinking responses to either angiotensin I or II. SQ 20,881 most likely inhibits brain ACE after central but not peripheral administration.
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Severs et al. (1973) studied this question.
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