Key result
Oral captopril at 100 mg/kg/day increased drinking and water diuresis in rats, a response abolished by chronic intraperitoneal infusion of ANG II or its antagonist.
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Does not support clinical changes in ACE inhibitor use; leaves open translational relevance of ANG II-mediated thirst in rodents.
Schiffrin et al. (1982) studied this question. Captopril was evaluated on Drinking and water diuresis. Oral captopril at 100 mg/kg/day increased drinking and water diuresis in rats, a response abolished by chronic intraperitoneal infusion of ANG II or its antagonist.
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