Key result
High-dose systemic or combined systemic and central captopril reduced drinking in response to caval ligation in rats, confirming the response depends on both angiotensin and nonangiotensin mechanisms.
Why the study?
Does captopril alter the drinking response induced by caval ligation in rats?
Population
Rats subjected to caval ligation
Comparison
Captopril administered subcutaneously and/or via… vs Caval ligation alone
Design
Preclinical
Authors
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No immediate clinical implications for ACE inhibition in thirst; extends dual-mechanism evidence in rodent hypovolemia models.
Does captopril alter the drinking response induced by caval ligation in rats?
In a rat model of caval ligation, preventing the conversion of angiotensin I to angiotensin II both systemically and in the brain reduces, but does not entirely prevent, the drinking response, confirming it is multifactorial.
Fitzsimons et al. (1982) studied Caval ligation-induced drinking. Captopril vs. Caval ligation alone was evaluated on Drinking response. High-dose systemic or combined systemic and central captopril reduced drinking in response to caval ligation in rats, confirming the response depends on both angiotensin and nonangiotensin mechanisms.
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