Resistance to experimental allergic encephalomyelitis in strain 2 guinea pigs correlates with a significantly higher humoral antibody response compared to susceptible strain 13 guinea pigs.
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Higher antibody titers may confer EAE resistance in guinea pigs; leaves open mechanistic and translational relevance to human demyelinating disease.
Differences were observed between guinea pigs of inbred strains 2 and 13 in both the susceptibility to the induction of experimental allergic encephalo-myelitis (EAE), and the immune response to the basic encephalitogen. Strain 2 guinea pigs, which are resistant to the induction of the disease, produce humoral antibodies against the encephalitogen in a titer 40–50-fold higher than guinea pigs of strain 13, which are sensitive to EAE.
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Webb et al. (1973) studied this question.
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