What question did this study set out to answer?

To determine whether periadipocytic lymphocyte rimming assessed via the Ki-67 proliferation index reliably differentiates subcutaneous panniculitis-like T-cell lymphoma from lupus erythematosus panniculitis.

May 10, 2018American Journal of Dermatopathology

Subcutaneous Panniculitis-Like T-Cell Lymphoma Versus Lupus Erythematosus Panniculitis: Distinction by Means of the Periadipocytic Cell Proliferation Index

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Authors

PSPanitta SitthinamsuwanSiriraj Hospital PPPenvadee PattanaprichakulSiriraj Hospital JTJitsupa TreetipsatitRatchaburi Hospital

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Implication

Comparative biopsy study reveals periadipocytic Ki-67 rimming distinguishes subcutaneous T-cell lymphoma from lupus panniculitis, highlighting its utility as a specific diagnostic biomarker.

Key Points

To determine whether periadipocytic lymphocyte rimming assessed via the Ki-67 proliferation index reliably differentiates subcutaneous panniculitis-like T-cell lymphoma from lupus erythematosus panniculitis.
Evaluated biopsy specimens from 19 cases of subcutaneous panniculitis-like T-cell lymphoma and 17 cases of lupus erythematosus panniculitis.
Assessed periadipocytic rimming using immunohistochemical markers Ki-67, CD8, and βF1, as well as clusters of CD123-positive cells.
Ki-67 periadipocytic rimming demonstrated a sensitivity of 79% and a specificity of 100% for subcutaneous panniculitis-like T-cell lymphoma (P < 0.01).
Periadipocytic rimming using CD8 and βF1 exhibited sensitivities of 100% and 89.5% and specificities of 52.9% and 88.2%, respectively (P < 0.01).
CD123-positive cells and overlapping lupus-like histopathological attributes were frequently observed in both disorders.

Cite This Study

Sitthinamsuwan et al. (2018) studied this question.

synapsesocial.com/papers/6a87e69f91c33485a1fe8607 https://doi.org/10.1097/dad.0000000000001173

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Implication

Comparative biopsy study reveals periadipocytic Ki-67 rimming distinguishes subcutaneous T-cell lymphoma from lupus panniculitis, highlighting its utility as a specific diagnostic biomarker.

Subcutaneous Panniculitis-Like T-Cell Lymphoma Versus Lupus Erythematosus Panniculitis: Distinction by Means of the Periadipocytic Cell Proliferation Index

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Implication

Key Points

Cite This Study

Subcutaneous Panniculitis-Like T-Cell Lymphoma Versus Lupus Erythematosus Panniculitis: Distinction by Means of the Periadipocytic Cell Proliferation Index

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Key Points

Cite This Study

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