Population
Hepatitis C virus helicase and DNA substrates with a range of tail and duplex lengths
Design
Preclinical
Authors
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May inform HCV antiviral targeting; leaves open translation from animal models to clinical use.
Multiple hepatitis C virus helicase molecules exhibit functional cooperativity to efficiently unwind long DNA duplexes, despite non-cooperative binding and uncoordinated ATPase cycles.
Levin et al. (2004) studied this question.
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