April 7, 2016Frontiers in PharmacologyOpen Access

Adiponectin Attenuates Angiotensin II-Induced Vascular Smooth Muscle Cell Remodeling through Nitric Oxide and the RhoA/ROCK Pathway

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Population

Rat aortic tissues

Comparison

Pre-treatment with Adiponectin, NO donor… vs Angiotensin II (Ang II) treatment alone

Design

Preclinical

Authors

WNWared Nour‐EldineHamad bin Khalifa University CGCrystal M. GhantousNotre Dame University – Louaize KZKazem ZibaraLebanese University

Discussion

Member takes

Implication

Suggests adiponectin as potential modulator of vascular hypertrophy; hypothesis-generating from animal data and should not yet change practice.

Structured PICO

Population

Rat aortic tissues

Intervention

Pre-treatment with Adiponectin (APN), NO donor S-nitroso-N-acetylpenicillamine (SNAP), or cGMP

Comparator

Angiotensin II (Ang II) treatment alone

Outcome

Ang II-induced vascular remodeling and hypertrophy (protein synthesis)surrogate

Adiponectin exerts anti-hypertrophic effects on vascular smooth muscle cells by inhibiting the RhoA/ROCK pathway and ROS formation via a nitric oxide-dependent mechanism.

Cite This Study

Nour‐Eldine et al. (2016) studied this question.

synapsesocial.com/papers/6a87ebd9a6bc66d2fbfe71b9 https://doi.org/10.3389/fphar.2016.00086

View Full Paper

Ask AI

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Implication

Suggests adiponectin as potential modulator of vascular hypertrophy; hypothesis-generating from animal data and should not yet change practice.

Adiponectin Attenuates Angiotensin II-Induced Vascular Smooth Muscle Cell Remodeling through Nitric Oxide and the RhoA/ROCK Pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adiponectin Attenuates Angiotensin II-Induced Vascular Smooth Muscle Cell Remodeling through Nitric Oxide and the RhoA/ROCK Pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider