Why the study?
Do beta-blockers reduce endothelin-1 synthesis and release in human endothelial cells?
Do beta-blockers reduce endothelin-1 synthesis and release in human endothelial cells?
Beta-blockers directly reduce endothelin-1 synthesis and release in human endothelial cells, providing a potential mechanism for their efficacy in cardiovascular diseases.
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In vitro beta-blocker effects on ET-1 may support mechanistic hypotheses; leaves open clinical translation in cardiovascular disease.
Garlichs et al. (1999) studied this question.
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