Endothelin-1 levels during exercise correlate with exercise capacity in heart failure patients, suggesting a potential mechanism for exercise intolerance.
May link ET-1 to HF exercise intolerance; hypothesis-generating and requires prospective trials before clinical consideration.
In conclusion, plasma levels of the endothelial-derived vasoconstrictor endothelin-1 (but not those of other neurohormonal vasoconstrictor factors), measured during exercise correlated closely with objective variables of exercise capacity in patients with heart failure. These findings suggest that endothelin-1 may contribute to exercise intolerance in patients with heart failure, perhaps by limiting the ability of the peripheral vasculature to dilate during exercise.
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Krum et al. (1995) studied this question.
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