Key result
Systolic function and exercise capacity are unrelated in chronic heart failure, but overlapping hemodynamic abnormalities in the heart, lung, and skeletal muscle lead to exercise intolerance.
Population
Patients with chronic heart failure
Design
Review
Authors
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Non-systolic factors drive exercise intolerance in chronic HF; leaves open targeted therapies addressing overlapping hemodynamic abnormalities.
Exercise intolerance in chronic heart failure is multifactorial, involving diastolic dysfunction, skeletal muscle abnormalities, vasodilatory defects, and neurohumoral changes, rather than just systolic dysfunction.
Myers et al. (1991) conducted a review in Chronic heart failure. Hemodynamic determinants was evaluated on Exercise capacity. Systolic function and exercise capacity are unrelated in chronic heart failure, but overlapping hemodynamic abnormalities in the heart, lung, and skeletal muscle lead to exercise intolerance.
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