Population
Patients with chronic heart failure
Design
Review
Authors
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Peripheral mechanisms may guide HF exercise assessment; leaves open optimal ACE inhibitor and training integration pending prospective trials.
Highlights that exercise intolerance in chronic heart failure is primarily mediated by peripheral vascular and skeletal muscle alterations rather than central hemodynamics, and can be improved with long-term ACE inhibition and physical training.
H. Drexler (1991) studied this question.
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