Key result
Exercise intolerance in chronic heart failure is driven by multiple factors including abnormalities in ventilatory control, lungs, peripheral circulation, and skeletal muscle.
Exercise intolerance in heart failure is multifactorial, involving peripheral and ventilatory abnormalities rather than just central hemodynamics.
Encourages comprehensive HF exercise assessment beyond hemodynamics; reinforces multifactorial mechanisms but leaves open targeted interventions.
A major aim in treating patients with chronic heart failure is to improve exercise capacity and quality of life. Experimental evidence does not support the view that central hemodynamic disturbance is the sole determinant of exercise capacity. Rather, multiple other factors including abnormalities of ventilatory control, the lungs, the peripheral circulation, and skeletal muscle appear to combine to generate symptoms and limit exercise.
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Harrington et al. (1997) conducted a review in chronic heart failure. Exercise intolerance in chronic heart failure is driven by multiple factors including abnormalities in ventilatory control, lungs, peripheral circulation, and skeletal muscle.
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