Why the study?
Adipose tissue thermogenesis and beige adipocyte recruitment represent potential targets for obesity and metabolic disease, but the mechanisms underlying adipocyte browning by different stimuli remain to be identified.
cAMP activation induces adipocyte browning via a biphasic transcriptomic and epigenomic remodeling process regulated by NFIL3, offering potential molecular targets for obesity treatment.
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Should not yet change obesity practice; leaves open NFIL3 as target for browning therapies.
So et al. (2022) studied this question.
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