Key result
Adipocyte fatty acid synthase deficiency enhances thermogenesis via alternatively activated macrophages, independent of sympathetic neurons.
Why the study?
The mechanisms by which adipocyte fatty acid synthase deficiency enhances thermogenic beige adipocyte appearance independent of sympathetic neuron involvement were unclear.
Population
Mouse inguinal white adipose tissues
Comparison
Adipocyte-specific fatty acid synthase deficiency (iAdFASNKO) vs cold exposure
Design
Preclinical single-cell transcriptomic analysis and functional studies
Authors
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Supports macrophage-driven thermogenesis independent of sympathetic input in mice; leaves open human translation and clinical relevance.
Adipocyte browning and thermogenesis can be driven by macrophage signaling independent of sympathetic nervous system activation.
Henriques et al. (2020) studied Thermogenesis in mouse adipose tissue. Adipocyte fatty acid synthase deficiency (iAdFASNKO) vs. Cold exposure was evaluated on Adipocyte browning and thermogenesis. Adipocyte fatty acid synthase deficiency enhanced adipose thermogenesis via alternatively activated macrophages, independent of sympathetic neuron involvement.
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