Why the study?
Childhood cancer survivors face increased risk of cardiac late effects that may be mitigated by physical activity and fitness, but comparisons of CVD risk and fitness associations with controls required investigation.
Does physical activity and fitness differentially impact cardiovascular disease risk factors in childhood cancer survivors compared to controls?
Population
157 childhood cancer survivors and 113 age- and sex-matched controls aged 9-18 years
Comparison
Childhood cancer survivors vs age- and sex-matched controls
Design
Matched observational cohort study
Authors
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May support prioritizing fitness in survivors; leaves open prospective validation for CVD outcomes.
Does physical activity and fitness differentially impact cardiovascular disease risk factors in childhood cancer survivors compared to controls?
Childhood cancer survivors have higher android fat mass than controls, but this risk factor is more strongly mitigated by physical fitness in survivors, highlighting the importance of targeted fitness interventions.
Bratteteig et al. (2023) studied this question.
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