Asymmetric Stereoablative Aryloxylation of 3‐Bromooxindoles with Bifunctional Catalyst

In this communication, the development of a highly enantioselective stereoablative protocol for the chemoselective aryloxylation of 3‐bromooxindoles with aryl alcohols have been realized. Promoted by easily available cinchona alkaloid derivatives (C6′−OH) under air‐ and moisture‐tolerant conditions, aryloxylation of a wide range of 3‐bromooxindoles bearing a 3′‐alkyl substituent proceeded in high yields and excellent enantioselectivities (up to 95% ee). The newly developed strategy expediently provided the 3‐phenoxy analogue of the core of alkaloid CPC‐1. magnified image