Comparison of the Chronic Kidney Disease Epidemiology Collaboration, the Modification of Diet in Renal Disease study and the Cockcroft-Gault equation in patients with heart failure

Figure 1. Flow chart of selection of patients from the Swedish Heart Failure Registry. CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; MDRD, Modification of Diet in Renal Disease Study.

Figure 2. (A) Distribution of patients according to the three renal function formulas. Number of patients at different level of renal function estimated by Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Modification of Diet in Renal Disease Study (MDRD) and Cockroft-Gault (CG). (B) Bland-Altman plots of CKD-EPI versus MDRD. (C) Bland-Altman plot of CKD-EPI versus CG.

Figure 3. Dose adjustment at different levels of renal function according to estimates with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Modification of Diet in Renal Disease Study (MDRD) and the Cockcroft-Gault (CG) formula. Overlap between formula means that all three formulas agree and suggest a dose reduction at the specific renal function cut-off. Non-overlap means that only one or two of the formulas suggest a dose reduction. (A) Table with suggested cut-off levels for the currently available non-vitamin K oral anticoagulants. (B) Cut-off eGFR < 50 mL/min/1.73 m2 by CKD-EPI or MDRD, or CrCl <50 mL/min with the CG formula among patients with known atrial fibrillation in SwedeHF. There were in total 20 975 patients with atrial fibrillation, of which 10 789 (51.4%) had an eGFR <50 mL/min/1.73 m2 or CrCl <50 mL/min obtained by any of the three formulas. Of these, 77.4% were identified by using only the CKD-EPI. CG identified 9459 (87.7%) and MDRD identified 8013 (74.3%). (C) Cut-off eGFR <30 mL/min/1.73 m2 by CKD-EPI or MDRD, or CrCl < 30 mL/min with the CG formula among patients with known atrial fibrillation in SwedeHF. Among the total 20 975 patients with atrial…

Figure 4. Receiver operating curve analysis for Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Modification of Diet in Renal Disease Study (MDRD) and Cockcroft-Gault (CG) renal function formula for 1-year mortality in the Swedish Heart Failure Registry.