Circulation: Heart Failure Editors’ Picks

Chronic Kidney Disease-Epidemiology Collaboration Group FormulaSummary: Compared to the radionuclide gold standard for the assessment of renal function, the Chronic Kidney Disease-Epidemiology Collaboration Group equation more accurately calculates estimated glomerular filtration rate than the Modification of Diet in Renal Disease equation.In an analysis of 20 754 patients (15 962 with heart failure with reduced ejection fraction and 4792 with heart failure with preserved ejection fraction), the authors found that using the Chronic Kidney Disease-Epidemiology Collaboration Group equation rather than the Modification of Diet in Renal Disease equation results in higher estimates of renal dysfunction (55% versus 51%) and better mortality risk stratification.Regardless of which equation was used, reduced estimated glomerular filtration rate was a stronger predictor of all-cause mortality in patients with heart failure with reduced ejection fraction than those with heart failure with preserved ejection fraction.Conclusions: Use of the CKD-EPI rather than the MDRD equation to calculate eGFR leads to higher estimates of renal dysfunction in HF and a more-accurate categorization of mortality risk.Renal function is more closely related to outcomes in HF-REF than in HF-PEF.3