Renal Dysfunction in Patients With Heart Failure With Preserved Versus Reduced Ejection Fraction
Why the study?
Does the CKD-EPI equation improve mortality risk stratification compared to the MDRD equation in patients with heart failure?
Population
20,754 patients with heart failure from 25 prospective studies, mean age 68 years.
Comparison
eGFR calculation using the Chronic Kidney… vs eGFR calculation using the Modification of Diet…
Design
Meta-analysis
Authors
Discussion
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Member takes
Implication
Supports CKD-EPI adoption for refined HF mortality stratification; reinforces its superiority over MDRD in meta-analytic evidence.
Structured PICO
Does the CKD-EPI equation improve mortality risk stratification compared to the MDRD equation in patients with heart failure?
P
Population
20,754 patients with heart failure (15,962 with HF-REF and 4,792 with HF-PEF) from 25 prospective studies, mean age 68 years.
I
Intervention
eGFR calculation using the Chronic Kidney Disease-Epidemiology Collaboration Group (CKD-EPI) equation
C
Comparator
eGFR calculation using the Modification of Diet in Renal Disease (MDRD) equation
O
Outcome
All-cause mortality across eGFR stratahard clinical
The CKD-EPI equation provides more accurate mortality risk categorization than the MDRD equation in heart failure patients, with renal function being more closely related to outcomes in HF-REF than in HF-PEF.
Cite This Study
McAlister et al. (2012) studied this question.