Experimental study demonstrates a catalyst-free one-pot synthesis of β,γ-unsaturated α-aminonitriles, suggesting a practical method for pharmaceutical scaffold generation.
An efficient method for synthesizing β,γ-unsaturated α-aminonitriles via a one-pot procedure using cinnamaldehydes, anilines and trimethylsilyl cyanide (TMSCN) as starting materials under catalyst-free conditions is reported. This one-pot, three-component reaction proceeds efficiently with a broad range of substrates and tolerates a wide variety of functional groups. Notably, the process features a simple work-up procedure and does not require transition-metal catalysts. Additionally, the reaction can be performed on gram scale without loss of efficiency.
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Wen et al. (2025) studied this question.
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