October 1, 1991AJP Heart and Circulatory Physiology

Positive inotropism in hypothermia partially depends on an increase in maximal Ca(2+)-activated force

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Population

Isolated perfused rabbit hearts (n=19)

Design

Preclinical

Authors

HKHideo KusuokaCardiac Imaging YIYoshio IkomaTokushima University SFShiho FutakiJuntendo University Hospital

Discussion

Member takes

Implication

Mild hypothermia effects on contractility require human validation before clinical use; leaves open mechanistic translation from animal myocardium.

Structured PICO

Population

Isolated perfused rabbit hearts (n=19)

Intervention

Mild hypothermia (myocardial cooling between 30 and 38 degrees C)

Outcome

Maximal Ca(2+)-activated pressure (MCAP)surrogate

Mild hypothermia induces positive inotropism primarily through an increase in myofilament Ca2+ responsiveness, explaining increased contractility without increased oxygen consumption.

Cite This Study

Kusuoka et al. (1991) studied this question.

synapsesocial.com/papers/6a87f1003fe66a1452bbed6a https://doi.org/10.1152/ajpheart.1991.261.4.h1005

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Implication

Mild hypothermia effects on contractility require human validation before clinical use; leaves open mechanistic translation from animal myocardium.

Positive inotropism in hypothermia partially depends on an increase in maximal Ca(2+)-activated force

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Positive inotropism in hypothermia partially depends on an increase in maximal Ca(2+)-activated force

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider