Key result
Hypothermia and rewarming significantly reduced myocardial contractility in rat papillary muscles, evidenced by a 30-40% decrease in peak twitch force and a ~30% decrease in maximal force.
Hypothermia and subsequent rewarming reduce myocardial contractility by decreasing calcium sensitivity of force via increased cTnI phosphorylation.
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May warrant caution during clinical hypothermia; leaves open translation to human myocardium.
Han et al. (2009) studied Hypothermia-induced cardiac contractile dysfunction. Hypothermia and rewarming vs. Controls (baseline temperature of 30 degrees C) was evaluated on Peak twitch force and maximal Ca(2+)-activated force (F(max)). Hypothermia and rewarming significantly reduced myocardial contractility in rat papillary muscles, evidenced by a 30-40% decrease in peak twitch force and a ~30% decrease in maximal force.
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