Key result
Rewarming after hypothermia depresses LV function and more than doubles myocardial lactate in rats.
Why the study?
Rewarming from accidental hypothermia is associated with fatal circulatory derangements, but the underlying pathophysiological mechanisms are not well understood.
Population
Rat hearts subjected to 4 hours of hypothermia at 15-13 degrees C
Comparison
Hypothermia and rewarming effects vs control conditions
Design
Experimental study on isolated rat hearts
Authors
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May underlie rewarming fatalities; leaves open translation from rat models to clinical practice.
Tveita et al. (1996) studied Accidental hypothermia. Hypothermia and rewarming vs. Control was evaluated on Myocardial mechanical function and energy metabolism. Rewarming after hypothermia in rats resulted in persistently depressed LV systolic pressure and cardiac output, and increased myocardial lactate (13.3 vs 5.7 nmol/mg).
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