Key result
Progressive surface cooling to 25°C followed by rewarming resulted in significantly reduced systolic, but not diastolic, left ventricular function, with cardiac output maintained by increased heart rate.
Why the study?
Does surface cooling to 25°C followed by rewarming cause left ventricular systolic dysfunction in an intact pig model?
Population
12 anesthetized castrated male juvenile pigs (weight 24-36 kg) from a native Norwegian stock.
Comparison
Surface cooling to 25°C followed by surface… vs Normothermic time-matched controls (n=4).
Design
Preclinical
Follow-up
Acute experiment
Authors
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Warrants caution with profound hypothermia in clinical settings; leaves open translation of isolated systolic effects to humans.
Does surface cooling to 25°C followed by rewarming cause left ventricular systolic dysfunction in an intact pig model?
p-value: p=≤0.05
Severe hypothermia and subsequent rewarming in a pig model induces isolated left ventricular systolic dysfunction and myocardial tissue degradation, compensated by increased heart rate.
Filseth et al. (2010) studied Hypothermia-induced cardiac dysfunction (n=12). Surface cooling and rewarming vs. Normothermic time-matched controls was evaluated on Left ventricular systolic and diastolic function (PRSW, dP/dtmax, Tau) (p=≤0.05). Progressive surface cooling to 25°C followed by rewarming resulted in significantly reduced systolic, but not diastolic, left ventricular function, with cardiac output maintained by increased heart rate.
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