Population
Recombinant, histidine-tagged 2C polypeptide and poliovirus RNA sequences
Comparison
Mutational studies of the 3'-terminal cloverleaf… vs Wild-type RNA sequences
Design
Preclinical
Authors
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May guide poliovirus antiviral targeting; animal data leave open human translation.
The poliovirus 2C polypeptide specifically binds to the 3'-terminal cloverleaf of negative-strand RNA, facilitated by the UGUUUU sequence in a double-stranded context, which has implications for viral replication.
Banerjee et al. (1997) studied this question.
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