The F380 residue in the S6 transmembrane segment of the BK channel acts as an integration node for communication between sensors and the pore, and the F380A mutant can facilitate detailed voltage sensor experiments.
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F380A mutant facilitates BK voltage sensor experiments; leaves open any clinical translation to human cardiovascular channelopathies.
Carrasquel-Ursulaez et al. (2014) studied this question.
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