Population
Xenopus laevis oocytes expressing cloned Ca(2+)-dependent K+ channel (hslo) from human myometrium
Design
Preclinical
Authors
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Contaminant Ba2+ explains hslo decay; challenges intrinsic inactivation models and requires chelator controls in future channel studies.
The apparent inactivation of cloned hslo Ca2+-dependent K+ channels at high positive potentials is an artifact caused by contaminant internal Ba2+ block rather than intrinsic channel gating.
Díaz et al. (1996) studied this question.
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