Why the study?
Does the described rapid procedure allow for laboratory control of simultaneous i.v. heparin and oral anticoagulant treatment without interrupting heparin?
Does the described rapid procedure allow for laboratory control of simultaneous i.v. heparin and oral anticoagulant treatment without interrupting heparin?
A rapid bedside procedure using capillary micro thrombin time allows for simultaneous monitoring of IV heparin and oral anticoagulants without interrupting heparin infusion.
May allow uninterrupted combined heparin-oral anticoagulant monitoring; leaves open prospective validation before practice adoption.
A procedure is described by which the laboratory control of simultaneous i.v. heparin and oral anticoagulant treatment may take place without interruption of the heparin treatment. Heparin is administered as an i.v. infusion in a dose which gives a capillary micro thrombin time of 6–13 sec according to a method described in this paper. Under these circumstances the standard Thrombotest (TT) procedure may be used without neutralization of the heparin with protamine. The recommended range of capillary micro thrombin time gives an optimal heparin effect without risk of overdosage. The capillary micro thrombin time may be recorded at the bedside simultaneously with the TT.
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Nyman et al. (1972) studied this question.
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