Population
Cardiomyocytes (in vitro model of hyperglycemic preconditioning and hypoxia)
Comparison
Angiotensin II exposure during the prehypoxic… vs Glucose-treated cells without ANG II exposure
Design
Preclinical
Authors
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May counteract glucose preconditioning in hypoxic cardiomyocytes; leaves open whether NHE or T-type Ca channel inhibition confers clinical protection.
Angiotensin II reverses the cardioprotective effects of hyperglycemic preconditioning in cardiomyocytes by altering calcium transport mechanisms during hypoxia.
Pastukh et al. (2004) studied this question.
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