Population
Neonatal rat cardiomyocytes
Design
Preclinical
Authors
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May blunt cardiomyocyte hypertrophy in hyperglycemia; leaves open translation to diabetic cardiomyopathy in patients.
Hyperglycemia inhibits capacitative calcium entry and hypertrophic responses in neonatal cardiomyocytes, providing a potential mechanistic explanation for the transition to diabetic cardiomyopathy and ischemic protection in diabetic models.
Pang et al. (2002) studied this question.
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