Population
Rat aortic smooth muscle (RASM) cells
Comparison
Culture in 25 mM glucose vs Culture in 5 mM glucose (control conditions)
Design
Preclinical
Authors
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Hyperglycemia may impair vascular smooth muscle Ca2+ handling; leaves open contribution to diabetic vasculopathy and requires in vivo confirmation.
Hyperglycemia impairs intracellular calcium signaling and capacitative calcium entry in rat aortic smooth muscle cells, an effect not reversed by myo-inositol.
Rivera et al. (1995) studied this question.
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