October 7, 1969Proceedings of the Royal Society B Biological Sciences

Uptake and re-use of sympathetic transmitter in the cat’s spleen

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Population

Cat's spleen (perfused with homologous blood and in situ)

Comparison

Stimulation of sympathetic nerves and addition… vs Spleen in situ

Design

Preclinical

Authors

ABA G BlakeleyPenn State Milton S. Hershey Medical Center LBLindor Brown LGL. B. GeffenThe University of Queensland

Discussion

Member takes

Implication

Should not yet change sympathetic modulation strategies; leaves open whether transmitter reuptake sustains nerve function in human cardiovascular disease.

Structured PICO

Population

Cat's spleen (perfused with homologous blood and in situ)

Intervention

Stimulation of sympathetic nerves and addition of noradrenaline to perfusate (up to 6 μg/min)

Comparator

Spleen in situ (for comparison of transmitter overflow)

Outcome

Transmitter overflow and uptake of noradrenalinesurrogate

This preclinical study provides evidence that the continued effectiveness of sympathetic nerves depends on the uptake and re-use of liberated transmitter.

Cite This Study

Blakeley et al. (1969) studied this question.

synapsesocial.com/papers/6a87f8a8138f07bd6f14b368 https://doi.org/10.1098/rspb.1969.0080

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Implication

Should not yet change sympathetic modulation strategies; leaves open whether transmitter reuptake sustains nerve function in human cardiovascular disease.

Uptake and re-use of sympathetic transmitter in the cat’s spleen

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Uptake and re-use of sympathetic transmitter in the cat’s spleen

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider