Key result
Splenic receptor stimulation increases sympathetic nerve activity, arterial pressure, and heart rate.
Why the study?
The role of splenic receptors in eliciting reflex cardiovascular responses and excitation of splenic and renal efferent nerves was not fully understood.
Population
Anesthetized, vagotomized, sinoaortic denervated cats
Comparison
Injection of warm physiological saline, capsaicin, bradykinin, and norepinephrine into vascularly isolated spleens
Design
Preclinical experimental study
Authors
Loading...
Splenic receptor reflexes modulate sympathetic outflow in cats; leaves open relevance to human cardiovascular regulation.
Activation of splenic receptors by stretch or chemical stimuli elicits reflex cardiovascular responses, demonstrating their role in the reflex control of circulation.
Calaresu et al. (1984) studied this question. Selective stimulation of splenic receptors was evaluated on Reflex responses of splenic and renal efferent nerves. Selective stimulation of splenic receptors via congestion, capsaicin, and bradykinin increased efferent activity of splenic and renal nerves, systemic arterial pressure, and heart rate in cats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: