Population
Porcine skeletal muscle sarcoplasmic reticulum (normal and malignant hyperthermia-susceptible)
Comparison
[3H]dantrolene and [3H]ryanodine binding assays… vs Normal vs malignant hyperthermia-susceptible…
Design
Preclinical
Authors
Loading...
Indicates distinct SR binding sites for dantrolene and ryanodine; leaves open separate molecular identities in humans.
The binding sites for dantrolene and ryanodine on the sarcoplasmic reticulum are pharmacologically distinct and may exist on separate molecules.
Palnitkar et al. (1997) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: