Why the study?
Does amlodipine improve total exercise time compared to nadolol in patients with stable exertional angina pectoris?
Population
80 patients with stable exertional angina pectoris
Comparison
Amlodipine 2.5-10 mg once daily for 26 weeks vs Nadolol 40-160 mg once daily for 26 weeks
Design
RCT, Randomized to receive amlodipine or nadolol, Double-blind
Follow-up
26 weeks
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Amlodipine matches nadolol on exercise tolerance with far fewer side effects; reinforces its preference for tolerability in stable angina.
Does amlodipine improve total exercise time compared to nadolol in patients with stable exertional angina pectoris?
Amlodipine and nadolol provide comparable antianginal efficacy in stable exertional angina, but amlodipine is associated with significantly fewer side effects.
A 1993 study studied this question.
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