African swine fever virus pA104R protein acts as a suppressor of type I interferon signaling

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Population

HEK-293 T cells

Design

Preclinical

Authors

Discussion

pA104R IFN antagonism is hypothesis-generating for ASFV immune evasion; leaves open in vivo relevance and therapeutic targeting.

Population

HEK-293 T cells

Intervention

African swine fever virus (ASFV) pA104R protein

Outcome

Type I interferon signaling activity (ISRE activity, transcription of ISGs, STAT1 phosphorylation)surrogate

ASFV pA104R protein acts as a potent antagonist of type I interferon signaling by attenuating STAT1 phosphorylation.

Chen et al. (2023) studied this question.

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