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October 26, 2017AJP Gastrointestinal and Liver Physiology

Transjugular intrahepatic portosystemic shunt: impact on systemic hemodynamics and renal and cardiac function in patients with cirrhosis

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Why the study?

Does transjugular intrahepatic portosystemic shunt (TIPS) alter systemic hemodynamics and renal and cardiac function in patients with cirrhosis?

Population

25 patients with cirrhosis

Comparison

Transjugular intrahepatic portosystemic shunt vs Baseline (before TIPS)

Design

Cohort

Follow-up

4 months

Authors

TBTroels M. BuskGentofte HospitalFBFlemming BendtsenUniversity of CopenhagenJPJørgen PoulsenHvidovre Hospital

Discussion

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Member takes

Overview

Supports TIPS consideration for volume and renal management in cirrhosis; leaves open definitive safety data from RCTs.

Structured PICO

Does transjugular intrahepatic portosystemic shunt (TIPS) alter systemic hemodynamics and renal and cardiac function in patients with cirrhosis?

P
Population
25 patients with cirrhosis
I
Intervention
Transjugular intrahepatic portosystemic shunt (TIPS)
C
Comparator
Baseline (before TIPS)
O
Outcome
Systemic, cardiac, and splanchnic hemodynamics, and renal and cardiac markerssurrogate

TIPS increases central blood volume through improved cardiac inotropy and improves renal function without negatively affecting myocardial function in patients with cirrhosis.

Cite This Study

Busk et al. (2017) studied this question.

synapsesocial.com/papers/6a87fccdeb5451a844aa65achttps://doi.org/10.1152/ajpgi.00094.2017
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Also Consider

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