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May 1, 1999GutOpen Access

Cardiac function and haemodynamics in alcoholic cirrhosis and effects of the transjugular intrahepatic portosystemic stent shunt

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Why the study?

Does transjugular intrahepatic portosystemic shunt (TIPS) alter cardiac function and haemodynamics in patients with alcoholic cirrhosis?

Population

17 patients with alcoholic cirrhosis and recent variceal bleeding

Comparison

Transjugular intrahepatic portosystemic shunt vs Baseline measurements (before TIPS)

Design

Cohort

Follow-up

9 hours

Authors

MHM. HuonkerInnsbruck Medical UniversityYSY O SchumacherQatar Orthopaedic and Sports Medicine HospitalAOA. OchsUniversity of Bremen

Discussion

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Overview

TIPS may unmask latent diastolic dysfunction in cirrhosis; leaves open whether pre-procedure cardiac screening improves safety.

Structured PICO

Does transjugular intrahepatic portosystemic shunt (TIPS) alter cardiac function and haemodynamics in patients with alcoholic cirrhosis?

P
Population
17 patients with alcoholic cirrhosis and recent variceal bleeding
I
Intervention
Transjugular intrahepatic portosystemic shunt (TIPS)
C
Comparator
Baseline measurements (before TIPS)
O
Outcome
Cardiac function and pulmonary and systemic circulation evaluated by echocardiography and catheterisationsurrogate

TIPS induces significant haemodynamic changes that reflect diastolic dysfunction of the hyperdynamic left ventricle, potentially unmasking preclinical cardiomyopathy in patients with alcoholic cirrhosis.

Cite This Study

Huonker et al. (1999) studied this question.

synapsesocial.com/papers/6a75ec16d17bc701ee162c8dhttps://doi.org/10.1136/gut.44.5.743
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decreased systemic vascular sensitivity to norepinephrine in portal hypertensive rats: role of hyperglucagonism1990 · 85 citations
  2. 2Relationship between cardiomyopathy and liver disease in chronic alcoholism1995 · 66 citations
  3. 3Tips: the New Kid on the Block. Laberge Jm, Ring Ej, Gordon Rl, Lake Jr, Doherty Mm, Somberg Ka, Roberts Jp, Ascher Nl . Creation of Transjugular Intrahepatic Portosystemic Shunts With the Wallstent Endoprosthesis: Results in 100 Patients. Radiology 1993;187:413-4201994 · 112 citations
  4. 4Limited cardiac preload reserve in conscious cirrhotic rats1991 · 45 citations
  5. 5Potential Role of Increased Sympathetic Activity in Impaired Sodium and Water Excretion in Cirrhosis1982 · 359 citations