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January 19, 2011BMC Medical GeneticsOpen Access

CYP2C19 and ABCB1gene polymorphisms are differently distributed according to ethnicity in the Brazilian general population

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Population

1,212 individuals, comprising 183 Amerindians and 1,029 subjects from the general population across 4…

Design

Cross-sectional

Authors

PRPaulo Rodrigues‐SantosRSRenata AG SoaresDSDiogo BG Santos

Discussion

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Overview

Ethnic differences in clopidogrel genotypes should not yet change prescribing; hypothesis-generating for ethnicity-guided dosing pending outcome trials.

Structured PICO

P
Population
1,212 individuals, comprising 183 Amerindians and 1,029 subjects from the general population across 4 regions of Brazil.
O
Outcome
Frequencies of CYP2C19 and ABCB1 polymorphisms and clopidogrel-predicted metabolic phenotypes according to ethnic groupssurrogate

Significant inter-ethnic differences exist in ABCB1 and CYP2C19 variant allele frequencies in the Brazilian population, which may impact individualized clopidogrel therapy.

Cite This Study

Rodrigues‐Santos et al. (2011) studied this question.

synapsesocial.com/papers/6a88015f4231b321a876e8e8https://doi.org/10.1186/1471-2350-12-13
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1<i>CYP2C9</i> and <i>VKORC1</i> Polymorphisms Are Differently Distributed in the Brazilian Population According to Self-Declared Ethnicity or Genetic Ancestry2012 · 24 citations
  2. 2Co-Existence of <i>CYP2C19</i> *1/*2 and <i>ABCB1c</i> .3435 CT Genotype has a Potential Impact on Clinical Outcome in CAD Patients Treated with Clopidogrel2023 · 1 citations
  3. 3Association of ABCB1 and CYP2C19 polymorphisms with major adverse cardiovascular complications in patients taking clopidogrel2026
  4. 4Evaluation of CYP2C19, P2Y12, and ABCB1 polymorphisms and phenotypic response to clopidogrel in healthy Indian adults2016 · 10 citations
  5. 5Association between CYP2C19 and ABCB1 polymorphisms and clopidogrel resistance in clopidogrel-treated Chinese patients2018 · 43 citations