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August 1, 1999American Journal of Tropical Medicine and Hygiene

Evidence for widespread infection of wild rats with hepatitis E virus in the United States.

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Authors

YKYamina Kabrane-LaziziNational Institutes of HealthJFJ FineCenters for Disease Control and PreventionJEJ ElmUniversity of Hawaiʻi at Mānoa

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Implication

Cross-sectional study reveals high hepatitis E virus seroprevalence in wild rats, suggesting a potential zoonotic reservoir for unexplained human infections.

Key Points

  • To evaluate the prevalence of hepatitis E virus infection among wild rat populations across multiple regions of the United States.
  • Collected and tested sera from 239 wild rats captured across geographically distinct regions including Maryland, Hawaii, and Louisiana.
  • Assayed serum samples for anti-hepatitis E virus (anti-HEV) IgG antibodies across urban and rural environments and analyzed prevalence across estimated age cohorts.
  • Anti-HEV antibodies were detected in 77% of rats from Maryland, 90% from Hawaii, and 44% from Louisiana.
  • Seropositivity was observed in both urban and rural settings, with anti-HEV IgG prevalence increasing in parallel with estimated rat age.

Cite This Study

Kabrane-Lazizi et al. (1999) studied this question.

synapsesocial.com/papers/6a880161010a27dee476ee80https://doi.org/10.4269/ajtmh.1999.61.331
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Also Consider

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  1. 1ELISA for Antibody to Hepatitis E Virus (HEV) Based on Complete Open-Reading Frame-2 Protein Expressed in Insect Cells: Identification of HEV Infection in Primates1993 · 220 citations
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  3. 3A novel virus in swine is closely related to the human hepatitis E virus1997 · 1,155 citations
  4. 4Enterically transmitted non-A, non-B hepatitis: serial passage of disease in cynomolgus macaques and tamarins and recovery of disease-associated 27- to 34-nm viruslike particles.1987 · 220 citations
  5. 5Detection of Hepatitis E Virus Infections among Domestic Swine in the Kathmandu Valley of Nepal1995 · 182 citations