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July 10, 2026Zoonotic DiseasesOpen Access

Rat Hepatitis E Virus (Rocahepevirus ratti): Global Evidence, Knowledge Gaps, and Zoonotic Risks

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Key result

Emerging rat hepatitis E virus requires active One Health surveillance to track global human impact.

Why the study?

Little is known about rat hepatitis E virus ecology in Africa, and limited data on hepatitis of unknown origin emphasize the need to understand its global distribution, epidemiology, and human health impact.

Design

Review

Authors

DKDennis KabantiyokABAsinamai Athliamai BitrusOOOlajide A. Owolodun

Discussion

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Member takes

Overview

rHEV emergence in Africa warrants targeted surveillance; leaves open its true zoonotic burden and transmission dynamics.

Key Points

  • The aim is to assess the global distribution, ecology, and public health implications of rat hepatitis E virus.
  • Review of existing global evidence and data regarding rat hepatitis E virus.
  • Analysis of known zoonotic risks and ecological factors related to Rattus norvegicus.
  • Emphasis on the One Health Approach for ongoing surveillance.
  • Global detection of rHEV in human, animal, and environmental samples is increasing.
  • Limited understanding of rHEV's ecology in Africa underscores the need for targeted research.
  • Monitoring in areas with high pig populations could significantly improve health outcomes for at-risk groups.

PICO

P
Population
Rat hepatitis E virus (rHEV) infection
E
Exposure / Comparator
Rat hepatitis E virus (rHEV)

Highlights the emerging zoonotic threat of rat hepatitis E virus and the need for global surveillance, particularly in under-monitored regions like Africa.

Limitations

  • Little is known about rHEV ecology in Africa
  • Limited data on hepatitis of unknown origin

Cite This Study

Kabantiyok et al. (2026) conducted a review in Rat hepatitis E virus (rHEV) infection. Rat hepatitis E virus (rHEV) was evaluated. Rat hepatitis E virus (rHEV) is an emerging zoonotic pathogen requiring active surveillance through a One Health Approach to understand its global distribution and impact on human health.

synapsesocial.com/papers/6a508bde6eeac72a437a0462https://doi.org/10.3390/zoonoticdis6030028
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rocahepevirus ratti: molecular evolution, zoonotic potential and public health impact2026 · 2 citations
  2. 2Spreading of the new rat hepatitis E virus (rHEV) into humans2026
  3. 3Rat Hepatitis E Virus (Rocahepevirus ratti): A Systematic Review of Its Presence in Water, Food-Related Matrices, and Potential Risks to Human Health2025 · 4 citations
  4. 4Investigating the Hepatitis E Virus (HEV) Diversity in Rat Reservoirs from Northern Italy2024 · 6 citations
  5. 5First Evidence of Spillover of <i>Rocahepevirus ratti</i> Into Humans in Thailand2025