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September 28, 2025Transboundary and Emerging DiseasesOpen Access

First Evidence of Spillover of Rocahepevirus ratti Into Humans in Thailand

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Authors

JYJulie YamaguchiGOGregory S. OrfLPLester J. Pérez

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Overview

Research indicates acute hepatitis cases linked to rocahepevirus ratti in humans, highlighting zoonotic risks.

Key Points

  • Rocahepevirus ratti likely caused chronic hepatitis in a human case linked to a heart transplant.
  • Next-generation sequencing revealed a complete genome from the infected patient, showcasing genetic connections to rats.
  • Principal component analysis suggests white bellied rats are the original hosts, with implications for zoonotic disease transmission.
  • Specific diagnostics are needed to track further outbreaks and understand the evolution of rocahepevirus ratti.

Cite This Study

Yamaguchi et al. (2025) studied this question.

synapsesocial.com/papers/68d913a34ddcf71ba560b96bhttps://doi.org/10.1155/tbed/9954682
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Spreading of the new rat hepatitis E virus (rHEV) into humans2026
  2. 2Rat Hepatitis E Virus (Rocahepevirus ratti): Global Evidence, Knowledge Gaps, and Zoonotic Risks2026
  3. 3Rocahepevirus ratti: molecular evolution, zoonotic potential and public health impact2026 · 2 citations
  4. 4P-1842. Clinical Characteristics of Rat Hepatitis E Virus (Rocahepevirus ratti) Infection: an emerging agent of viral hepatitis in humans2026 · 1 citations
  5. 5Enhanced surveillance, subtyping, and host adaptation analysis reveal genotype-wide zoonotic potential of rat hepatitis E virus2025 · 9 citations