Key result
Human-derived rat hepatitis E virus strains clustered across multiple clades and subtypes, exhibiting significant selection relaxation in ORF2 (k = 0.19; p = 5.48E-04) and genotype-wide zoonotic potential.
Observational (n=22)
Effect estimate: k = 0.19
p-value: p=5.48E-04
Rat hepatitis E virus exhibits genotype-wide zoonotic potential, highlighting the need for enhanced global surveillance in humans and rodents.
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May warrant expanded rat HEV surveillance in humans; leaves open zoonotic transmission scale and clinical guidelines.
Lo et al. (2025) conducted an observational in Rat hepatitis E virus (rHEV) infection (n=22). Human-derived rHEV strains was evaluated on Selection relaxation in ORF2 of human-derived rHEV (k = 0.19, p=5.48E-04). Human-derived rat hepatitis E virus strains clustered across multiple clades and subtypes, exhibiting significant selection relaxation in ORF2 (k = 0.19; p = 5.48E-04) and genotype-wide zoonotic potential.
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