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April 12, 2026Nature CommunicationsOpen Access

Rocahepevirus ratti: molecular evolution, zoonotic potential and public health impact

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Authors

ARAntonio Rivero-JuarezRJReimar JohneSSSiddharth Sridhar

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Overview

This review explores zoonotic hepatitis E infection in urban rodents, highlighting unmet diagnostic needs and public health implications.

Key Points

  • To synthesize current knowledge on Rocahepevirus ratti, focusing on its evolution, zoonotic potential, and public health impact.
  • Review of existing literature on ratHEV ecology and molecular virology
  • Analysis of reported human cases across Asia and Europe
  • Assessment of diagnostics and surveillance strategies
  • Over 50 confirmed human cases of ratHEV reported in Asia and Europe
  • Infections mostly self-limiting, but can be severe in immunocompromised individuals
  • Challenges in case detection due to genetic diversity and lack of specific assays

Cite This Study

Rivero-Juarez et al. (2026) studied this question.

synapsesocial.com/papers/69db36a04fe01fead37c4a33https://doi.org/10.1038/s41467-026-71382-3
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rat Hepatitis E Virus (Rocahepevirus ratti): Global Evidence, Knowledge Gaps, and Zoonotic Risks2026
  2. 2Rat Hepatitis E Virus (Rocahepevirus ratti): A Systematic Review of Its Presence in Water, Food-Related Matrices, and Potential Risks to Human Health2025 · 4 citations
  3. 3Spreading of the new rat hepatitis E virus (rHEV) into humans2026
  4. 4Evolution of rat hepatitis E virus: recombination, divergence and codon usage bias2023 · 1 citations
  5. 5Enhanced surveillance, subtyping, and host adaptation analysis reveal genotype-wide zoonotic potential of rat hepatitis E virus2025 · 9 citations