Key result
Rat hepatitis E virus began expanding around 1956 and evolves at a high rate.
Why the study?
Rat hepatitis E virus is an emerging zoonotic pathogen posing an increasing threat to public health worldwide, requiring a better understanding of its epidemiology and evolution.
Population
Rat hepatitis E virus isolates sampled so far
Design
Phylogeographic, recombination, Bayesian coalescent, and codon usage bias analysis
Authors
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Supports zoonotic surveillance for RHEV; leaves open its human transmission risk and need for prospective studies.
RHEV is an emerging zoonotic pathogen that began expanding around 1956, evolves at a high rate, and exhibits unique codon usage biases compared to its host.
Zhao et al. (2023) studied Rat hepatitis E virus (RHEV) (n=149). Genomic and phylogenetic analysis was evaluated. Bayesian coalescent analysis of 149 rat hepatitis E virus sequences revealed that the virus began to expand around 1956 and evolves at a high rate of 1.06 × 10^-2 substitutions/site/year.
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