High intensity focused ultrasound for the treatment of rat tumours
Authors
Discussion
Loading...
Member takes
Implication
Preclinical study demonstrates complete tumour ablation in rats using contiguous focused ultrasound beams, highlighting the need for full-volume coverage to prevent regrowth.
Key Points
- To assess the therapeutic efficacy of focused ultrasound lesion arrays in destroying implanted liver tumours in a rat model.
- Exposed discrete implanted rat liver tumours to arrays of 1.7 MHz focused ultrasound lesions.
- Applied focal peak intensities between 1.4 and 3.5 kW/cm² for a 10-second exposure duration per lesion.
- Assessed tumour response and recurrence histologically following contiguous versus non-contiguous lesion coverage.
- Complete exposure of the entire tumour volume to focused ultrasound resulted in no histologically detectable tumour growth.
- Non-contiguous ultrasonic lesion arrays permitted tumour regrowth, which was confirmed by preliminary histological examination.
Cite This Study
Haar et al. (1991) studied this question.