Why the study?
Do plasma beta endorphin concentrations increase before vasodepressor syncope during tilt testing?
Population
24 patients undergoing tilt testing for investigation of unexplained syncope at a tertiary referral centre.
Comparison
70 degrees head up tilt testing with frequent… vs Patients with a negative tilt test (no syncope).
Design
Cohort
Follow-up
Duration of tilt test
Authors
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May implicate endogenous opioids in vasodepressor syncope; hypothesis-generating for blockade trials before practice change.
Do plasma beta endorphin concentrations increase before vasodepressor syncope during tilt testing?
An increase in plasma beta endorphins precedes vasodepressor syncope, supporting a pathophysiological role for endogenous opioids in this condition.
Wallbridge et al. (1994) studied this question.
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